Coronavirus, Coronavirus Disease 2019 (COVID-19 or 2019-nCoV)

Coronavirus disease 2019 (COVID-19)

• Virus, Difference Between Virus & Bacteria, DNA & RNA Viruses
• Coronavirus, Coronavirus Disease 2019 (COVID-19 or 2019-nCoV) <===
• Immune System, T– Cells & Coronavirus, Cytokine storm
• Covid-19 Tests: RT-PCR, Rapid Antigen Test & Serological Test
• Proposed Vaccines, Treatments in the Context of COVID-19

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What is Coronavirus?

• A SARS-CoV-2 virion (a single virus particle) is about 80 nanometers in diameter.
• The pathogen is a member of the coronavirus family, which includes the viruses responsible for SARS & MERS infections.
• It is an RNA virus with ribonucleic acid (RNA) as its genetic material instead of DNA.
• That means the virus blends with its host’s DNA & can mutate rapidly.
• It’s covered by spiky protrusions like on a crown (hence the name Corona), which are in turn enveloped in a layer of fat (the reason soap does a good job of destroying the virus).

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2019-nCoV (COVID-19)

• COVID-19 is an infectious Zoonotic Disease, caused by a newly discovered SARS–CoV–2 coronavirus.
• SARS–CoV–2 can trigger what doctors call a respiratory tract infection.
• Disease- nCoV- n=novel meaning new, Co =corona, V=Virus
• Disease- Covid 19- Co=corona, Vi=virus, d=disease,19=2019
• Virus – SARS-CoV-2- meaning-severe acute respiratory syndrome coronavirus 2.
• Viruses, & the diseases they cause, often have different names. E.g. HIV is the virus that causes AIDS.
• Covid-19, like SARS, MERS, AIDS, & Ebola, is a zoonotic disease—it jumped from another species to humans.
• This probably happened in late 2019 in Wuhan, China.
• Scientists believe bats are the likeliest reservoir.
• It might have jumped from bats to pangolins & then to humans.
• Symptoms include dry cough, fever, fatigue, muscle aches & acute breathing difficulty.
• The incubation period for the virus can last from 10 to 14 days.
• The infection can cause pneumonia, respiratory distress, kidney failure & in some cases, in which immunity is weak, even death.
• As of now, there is no vaccine against coronavirus infection. There is also no cure for the 2019-nCoV.

Zoonotic Disease

• Zoonotic diseases (also known as zoonoses) are caused by germs that spread between animals & people.
• Zoonoses may be bacterial, viral, or parasitic, or may involve unconventional agents.
• As well as being a public health problem, many of the major zoonotic diseases prevent the efficient production of food of animal origin & create obstacles to international trade in animal products.

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Previous Coronavirus Outbreaks

• So far, there are four known disease-causing coronaviruses, among which the best known are the SARS coronavirus & the Middle East Respiratory Syndrome (MERS) coronavirus.
• Severe Acute Respiratory Syndrome (SARS) outbreak in China in 2002-03 killed nearly 800 people.
• The SARS coronavirus is thought to be an animal virus from a yet-uncertain animal reservoir, perhaps bats, that spread to other animals & first infected humans in the Guangdong province of China in 2002.
• The MERS coronavirus was passed on from camels to humans in Saudi Arabia in 2012.

How does Coronavirus get into Human Cells?

• The virus’s protein spikes attach to a protein on the surface of host cells, called ACE2.
• ACE2 acts as the receptor for the SARS-CoV-2 virus and allows it to infect the cell.
• Normally, ACE2 plays a role in regulating blood pressure.

Entering a Vulnerable Cell

• The virus enters the body through the nose, mouth or eyes, then attaches to cells in the airway that produce a protein called ACE2.

Releasing Viral RNA

• The virus infects the cell by fusing its oily membrane with the membrane of the cell.
• Once inside, the coronavirus releases a snippet of genetic material called RNA.

Hijacking the Cell

• The virus’s genome is less than 30,000 genetic “letters” long (Ours is over 3 billion).
• The infected cell reads the RNA & begins making proteins that will keep the immune system at bay & help assemble new copies of the virus.
• Antibiotics kill bacteria & do not work against viruses.
• Researchers are testing antiviral drugs that might disrupt viral proteins & stop the infection.

Making Viral Proteins

• As the infection progresses, the machinery of the cell begins to churn out new spikes & other proteins that will form more copies of the coronavirus.

Assembling New Copies

• New copies of the virus are assembled & carried to the outer edges of the cell.

Spreading the Infection

• Each infected cell can release millions of copies of the virus before the cell finally breaks down & dies.
• The viruses may infect nearby cells, or end up in droplets that escape the lungs

Immune Response

• Most Covid-19 infections cause a fever as the immune system fights to clear the virus.
• In severe cases, the immune system can overreact & start attacking lung cells.
• The lungs become obstructed with fluid & dying cells, making it difficult to breathe.
• A small percentage of infections can lead to acute respiratory distress syndrome, & possibly death.

Leaving the Body

• Coughing & sneezing can expel virus-laden droplets onto nearby people & surfaces, where the virus can remain infectious for several hours to several days.

Stages of Coronavirus Transmission

• Stage 1 | Imported Cases: These are those who have travelled to virus-hit foreign countries & have come back to India.
• Stage 2 | Local Transmission: These are those cases who have come in contact with patients who have a travel history.
• Stage 3 | Community Transmission: Community transmission is when a patient not exposed to any infected person or one who has travelled to any of the affected countries tests positive. Large areas get affected when community transmission takes place.
• Stage 4 | Epidemic: This is the last & the worst stage where the disease takes the shape of an epidemic with no clear endpoint like it did in China.

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What is Vertical Transmitted Infection?

• A vertically transmitted infection is an infection caused by pathogens (such as bacteria & viruses) that use mother–to–child transmission.
• It is transmitted directly from the mother to an embryo, fetus, or baby during pregnancy or childbirth.

Difference between Outbreak, Endemic, Epidemic & Pandemic

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What is Case Fatality Rate (CFR)

• Case Fatality Rate (CRF) measures the severity of a particular disease by defining the total number of deaths as a proportion of reported cases of a specific disease at a specific time.
• CFR is presented as a percentage (0%–100%) or a ratio (between 0–1) & measures the number of confirmed deaths among the number of confirmed diagnosed cases of a particular disease at a given time.

CFR of Common Diseases

Specific CFRs of particular diseases if left untreated or unvaccinated for include:

• Bubonic Plague – 60%
• Spanish Flu (1918) – 2.5%
• Ebola – 90%
• Naegleriasis – 99%
• Smallpox – 95%
• Seasonal Influenza – 0.1%
• HIV/AIDS – 80%
• Dengue Fever – 26%
• Malaria – 0.3%
• Typhoid – 10–20%
• SARS – 9–11%
• MERS – 34.4%