PMF IAS Current Affairs
PMF IAS Current Affairs
  • Context (TH): The Lancet published a study related to the repurposing of an existing drug, Abatacept, to prevent the onset of rheumatoid arthritis.
  • The study aimed to evaluate the feasibility, efficacy, and acceptability of treating high-risk individuals with Abatacept.
  • Abatacept acts as a signalling pathway to initiate the appropriate immune response.
  • High-risk individuals for RA can be identified years before developing the disease through the detection of autoantibodies associated with RA.
  • The study showed that targeting adaptive immunity with Abatacept in high-risk individuals can prevent the onset of RA.
  • Abatacept, classified as a biological drug, is not available in India due to poor sales.
  • Early prevention of RA is significant, especially for individuals with a family history.
  • There are challenges in convincing individuals with blood abnormalities but no physical symptoms to start preventive treatment.

Rheumatoid Arthritis

  • RA is a chronic autoimmune condition primarily affecting the joints.
  • It leads to pain, joint swelling, stiffness, and reduced mobility.
  • While the exact cause of RA remains unclear, the immune system mistakenly attacks the body’s tissues, resulting in joint damage.
  • RA can also impact other organs like the heart, lungs, and skin.
  • RA can significantly reduce a patient’s quality of life and may lead to medical problems outside the joints.
  • Lifestyle changes such as quitting smoking, regular exercise, and a healthy diet are recommended on a mass scale to reduce the risk of RA.
  • Maintaining adequate vitamin D levels may help regulate the immune response and reduce inflammation associated with RA.
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