Nobel Prize in Medicine 2023, mRNA Vaccines, Katalin Karikó and Drew Weissman
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Nobel Prize in Medicine 2023
- Context (TH | IE): The 2023 Nobel Prize in Physiology or Medicine has been awarded to Hungarian biochemist Katalin Karikó and American physician-scientist Drew Weissman. Their work enabled the development of mRNA vaccines against COVID-19.
What are mRNA Vaccines, and Why were They crucial During COVID-19?
- Vaccines are designed to stimulate the immune system against specific infectious diseases.
- Traditionally, vaccines used weakened or inactivated viruses to stimulate antibody production.
- As technology advanced, vaccines began using partial viral genetic code instead of the whole virus.
- But large-scale development of these vaccines requires cell culture (growing cells under controlled conditions), which is time-consuming.
- During the COVID-19, this time-consuming way of producing vaccines proved ineffective. This is where mRNA technology proved crucial.
- This technology existed since the 1980s but wasn’t perfected for large-scale vaccine production.
- Basically, mRNA vaccines use genetically engineered mRNA to instruct cells to make the protein needed to fight a particular virus.
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What Kariko and Weissman did to Make the mRNA Technology Viable for Vaccines?
- The problem with mRNA vaccines was that the body’s immune system recognised the lab-engineered mRNA as foreign and launched an immune response against it.
- Kariko/Weissman found a way to modify the mRNA, which abolished the immune response generation by bodies against them, making mRNA tech viable for large-scale vaccine production.
- COVID-19 vaccines Moderna (US) and Pfizer (US) used this mRNA technology.
Nobel Prize
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