Understanding the science behind mRNA technology
- All living organisms (animals, plants, and bacteria) possess both DNA and RNA. An exception to this rule is seen in viruses, which contain either DNA or RNA, not both.
- DNA holds instructions on how to make proteins, but it never leaves the cell’s nucleus.
- It is RNA, specifically messenger RNA (mRNA), that provides these instructions to the ribosomes. Ribosomes are the sites where proteins are synthesised.
- The nucleus creates RNA (mRNA), a copy of DNA’s instructions.
- mRNA then travels to the ribosomes, taking the information.
- The ribosome reads mRNA’s sequence & translates it into a string of amino acids, forming proteins.
mRNA
- mRNA, or messenger RNA, is a type of RNA that acts as a messenger for building proteins.
- While various types of RNA contribute to protein synthesis, mRNA specifically carries the recipe for a protein.
- Scientists use this function of mRNA to instruct cells to produce specific viral proteins.
mRNA vaccines
- Scientists identify a specific protein that is crucial for infection. In the case of COVID-19, this is often the spike protein.
- The identified protein sequence will be used to create the mRNA instructions.
- In the laboratory, a synthetic mRNA is created and encapsulated within lipid nanoparticles. These lipid nanoparticles protect the mRNA and help it enter cells.
- The combination of synthetic mRNA and lipid nanoparticles forms the basis of the mRNA vaccine.
- Once the mRNA vaccine is administered, the lipid nanoparticles deliver the mRNA into the cells of the vaccinated individual.
- Cells in the muscle take up the mRNA, recognising it as genetic instructions.
- The ribosomes read the mRNA and follow the instructions to produce the viral protein (e.g., the spike protein).
- The immune system recognises the synthesised viral protein as foreign and mounts an immune response, producing antibodies and activating immune cells.

- mRNA technology is versatile and adaptable, holding promise not only for vaccines but also for treating diseases such as cancer and genetic disorders
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