In the context of hereditary diseases, consider the following statements: 1)Passing on mitochondrial diseases from parent to child can be prevented by mitochondrial replacement therapy either before or after in vitro fertilization of egg. 2) A child inherits mitochondrial diseases entirely from mother and not from father. [2021]

In the context of hereditary diseases, consider the following statements:

Passing on mitochondrial diseases from parent to child can be prevented by mitochondrial replacement therapy either before or after in vitro fertilization of egg.
A child inherits mitochondrial diseases entirely from mother and not from father.

Mitochondrial donation (sometimes called mitochondrial replacement therapy) is a group of techniques that allow women whose eggs contain unhealthy mitochondria to have healthy children. There are several ways to undertake mitochondrial donation, but, in all cases, the goal is to create an embryo with the nuclear genome of the mother and father, but the mitochondria (and therefore the mitochondrial DNA) of a donor.
There are two different methods and both use In Vitro fertilisation (IVF). In the first, the nuclear genetic material from the mother’s egg is transferred into a donor egg which has had its own nuclear genetic material removed. This egg is then fertilised with the father’s sperm to create an embryo. The second technique is identical except it takes place after fertilisation, in a single-celled embryo rather than an egg. It cannot cure people with existing mitochondrial disease or prevent mitochondrial disease caused by a mutation in nuclear DNA.

Mitochondria are inherited maternally, meaning they are passed from the mother to the child. The sperm provides almost no cytoplasm (and hence no mitochondria) to the fertilized egg.

Mitochondrial diseases are genetic disorders caused by defects in mitochondria, the energy-producing structures in cells.
Role of Mitochondria: Mitochondria generate energy for cellular functions and are essential for the proper function of high-energy tissues like the brain, nerves, muscles, kidneys, heart, liver. Impact of
Defects: Defects in mitochondria impair their ability to produce energy, affecting organ function and leading to a range of symptoms such as brain damage, organ failure, and muscle wastage.
Symptoms: Symptoms can become more severe over time, often leading to debilitating conditions without a cure, though treatments may alleviate some effects.
Incidence: Mitochondrial diseases affect approximately 1 in 5,000 people.